Severe PAH Secondary to Dasatinib: PAH Treatment Required?

PAH Exposure

A 140 volume 117 | number 4 | April 2009 • Environmental Health Perspectives PAH Exposure doi:10.1289/ehp.0800445 We were very interested to read the article by Choi et al. (2008). The difference between maternal exposure and our own data on actual concentrations of poly cyclic aromatic hydro carbons (PAHs) in the human male fetal liver (Fowler et al. 2008) was striking. Eight of the PAH exposu...

Drugs currently used for treatment of PAH

Using deuterated PAH amendments to validate chemical extraction methods to predict PAH bioavailability in soils.

Validating chemical methods to predict bioavailable fractions of polycyclic aromatic hydrocarbons (PAHs) by comparison with accumulation bioassays is problematic. Concentrations accumulated in soil organisms not only depend on the bioavailable fraction but also on contaminant properties. A historically contaminated soil was freshly spiked with deuterated PAHs (dPAHs). dPAHs have a similar fate ...

PAH cleanup in Illinois.

Value of Monitoring Serum Immunoglobulins Questioned Our journal club's review of the recent article by Szczeklik al. (EHP 102:302304) found fault on many levels, especially with the concluding recommendation. It would be neither practical nor useful for workers exposed chronically to PAHs to have serum immunoglobulin levels monitored regularly. The use of cross-sectional data regarding serum i...

Formation of genotoxic nitro-PAH compounds in fish exposed to ambient nitrite and PAH.

Mutagenic nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) have been known to arise in the environment through direct emissions from combustion sources and nitration of PAHs, primarily in the atmosphere. Here, we report the formation of nitro-PAH compounds in fish contaminated with PAH and exposed to nitrite (NO2-) in the ambient water. Electrospray ionization mass spectrometric analysis ...